Amorolfine is a morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis. Amorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase.
- Mechanism
- Curator reviewed · 3 references
Amorolfine mediates its antifungal effects by interfering with ergosterol biosynthesis in the fungal cell membrane by inhibiting delta(14)-sterol reductase and cholestenol delta-isomerase. It alters the membrane sterol content, thereby changing the membrane permeability and disrupting metabolic processes.
- Formula / weight
- C21H35NO · 317.517 g/mol (avg)
- Also known as
- Amorolfin
- Code names
- RO 14-4767/000
Resolves to
MQHLMHIZUIDKOO-AYHJJNSGSA-NSMILES[H]C(C)(CN1C[C@]([H])(C)O[C@]([H])(C)C1)CC1=CC=C(C=C1)C(C)(C)CCWhat you can answer from here — as of September 16, 2026
Which drugs share a target with Amorolfine, and which of those have an active Phase 3 trial?
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